The Effect of Ouabain on the Hydration of the Cornea.
نویسندگان
چکیده
The effect of ouabain on the hydration of the rabbit cornea has been studied. The glycoside was found to prevent the dehydration of the cornea during temperature reversal procedures and its application to the cornea in vivo results in significant corneal swelling. A comparison of the effect of ouabain on the cornea to the drug's effect on electrolyte transport systems in the tissues suggests that the cornea regulates its hydration by a transport of electrolytes, presumably across the endothelium.
منابع مشابه
The effect of ouabain on the rabbit corneal endothelium.
With the method of in vitro incubation of the isolated rabbit cornea with the modified KEI medium, the effects of ouabain applied to the endothelial surface have been investigated. The change in corneal hydration with varying concentrations of ouabain was determined; one-half maximum rate of corneal swelling was found at an ouabain concentration of 3 x 10~ moles per liter. Endothelial permeabil...
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عنوان ژورنال:
- Investigative ophthalmology
دوره 4 شماره
صفحات -
تاریخ انتشار 1965